The SARS coronavirus nucleocapsid protein–forms and functions

C Chang, MH Hou, CF Chang, CD Hsiao, T Huang - Antiviral research, 2014 - Elsevier
The nucleocapsid phosphoprotein of the severe acute respiratory syndrome coronavirus
(SARS-CoV N protein) packages the viral genome into a helical ribonucleocapsid (RNP) …

[HTML][HTML] Orthobunyaviruses: recent genetic and structural insights

RM Elliott - Nature Reviews Microbiology, 2014 - nature.com
Orthobunyaviruses, which have small, tripartite, negative-sense RNA genomes and
structurally simple virions composed of just four proteins, can have devastating effects on …

High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses

L Shen, J Niu, C Wang, B Huang, W Wang… - Journal of …, 2019 - Am Soc Microbiol
Coronaviruses (CoVs) act as cross-species viruses and have the potential to spread rapidly
into new host species and cause epidemic diseases. Despite the severe public health threat …

Current progress in antiviral strategies

Z Lou, Y Sun, Z Rao - Trends in pharmacological sciences, 2014 - cell.com
The prevalence of chronic viral infectious diseases, such as human immunodeficiency virus
(HIV), hepatitis C virus (HCV), and influenza virus; the emergence and re-emergence of new …

[HTML][HTML] The mechanism of genome replication and transcription in bunyaviruses

H Malet, HM Williams, S Cusack, M Rosenthal - PLoS pathogens, 2023 - journals.plos.org
Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …

[HTML][HTML] Early bunyavirus-host cell interactions

A Albornoz, AB Hoffmann, PY Lozach, ND Tischler - Viruses, 2016 - mdpi.com
The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide.
Several of these viruses cause severe diseases in livestock and humans. With an increasing …

Bunyavirales ribonucleoproteins: the viral replication and transcription machinery

Y Sun, J Li, GF Gao, P Tien, W Liu - Critical reviews in microbiology, 2018 - Taylor & Francis
The Bunyavirales order is one of the largest groups of segmented negative-sense single-
stranded RNA viruses, which includes many pathogenic strains that cause severe human …

[HTML][HTML] Nucleocapsid structure of negative strand RNA virus

M Luo, JR Terrell, SA Mcmanus - Viruses, 2020 - mdpi.com
Negative strand RNA viruses (NSVs) include many important human pathogens, such as
influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs …

The native orthobunyavirus ribonucleoprotein possesses a helical architecture

FR Hopkins, B Álvarez-Rodríguez, GR Heath, K Panayi… - MBio, 2022 - Am Soc Microbiol
The Bunyavirales order is the largest group of negative-sense RNA viruses, containing
many lethal human pathogens for which approved anti-infective measures are not available …

Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 Å resolution

S Dong, P Yang, G Li, B Liu, W Wang, X Liu, B Xia… - Protein & …, 2015 - academic.oup.com
Ebola virus (EBOV) is a key member of Filoviridae family and causes severe human
infectious diseases with high morbidity and mortality. As a typical negative-sense single …