Paracrine mechanisms in adult stem cell signaling and therapy

M Gnecchi, Z Zhang, A Ni, VJ Dzau - Circulation research, 2008 - Am Heart Assoc
Animal and preliminary human studies of adult cell therapy following acute myocardial
infarction have shown an overall improvement of cardiac function. Myocardial and vascular …

Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use

GP Fadini, D Losordo, S Dimmeler - Circulation research, 2012 - Am Heart Assoc
Diverse subsets of endothelial progenitor cells (EPCs) are used for the treatment of ischemic
diseases in clinical trials, and circulating EPCs levels are considered as biomarkers for …

On vasa vasorum: A history of advances in understanding the vessels of vessels

JA Phillippi - Science Advances, 2022 - science.org
The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood
vessels. Although these dynamic microvessels have been studied for centuries, the …

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart

M Mirotsou, TM Jayawardena, J Schmeckpeper… - Journal of molecular and …, 2011 - Elsevier
Stem cells play an important role in restoring cardiac function in the damaged heart. In order
to mediate repair, stem cells need to replace injured tissue by differentiating into specialized …

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

S Rafii, D Lyden - Nature medicine, 2003 - nature.com
Emerging evidence suggests that bone marrow–derived endothelial, hematopoietic stem
and progenitor cells contribute to tissue vascularization during both embryonic and postnatal …

Pathophysiological consequences of VEGF-induced vascular permeability

SM Weis, DA Cheresh - Nature, 2005 - nature.com
Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts
vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and …

Monitoring of bone marrow cell homing into the infarcted human myocardium

M Hofmann, KC Wollert, GP Meyer, A Menke… - Circulation, 2005 - Am Heart Assoc
Background—Intracoronary transfer of autologous bone marrow cells (BMCs) promotes
recovery of left ventricular systolic function in patients with acute myocardial infarction …

Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

S Saadoun, MC Papadopoulos, M Hara-Chikuma… - Nature, 2005 - nature.com
Abstract Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular
endothelia, where it increases cell membrane water permeability,,. The role of AQP1 in …

Mesenchymal stem cell therapy: A promising cell‐based therapy for treatment of myocardial infarction

AES Shafei, MA Ali, HG Ghanem… - The journal of gene …, 2017 - Wiley Online Library
For decades, mesenchymal stem (MSCs) cells have been used for cardiovascular diseases
as regenerative therapy. This review is an attempt to summarize the types of MSCs involved …

Can we engineer a human cardiac patch for therapy?

J Zhang, W Zhu, M Radisic… - Circulation …, 2018 - Am Heart Assoc
Some of the most significant leaps in the history of modern civilization—the development of
article in China, the steam engine, which led to the European industrial revolution, and the …