The POLG gene encodes the mitochondrial DNA polymerase that is responsible for
replication of the mitochondrial genome. Mutations in POLG can cause early childhood …

Mitochondria play a central role in cellular energy provision. The organelles contain their
own genome with a modified genetic code. The mammalian mitochondrial genome is …

INTRODUCTION Mitochondria are endosymbiotic organelles that have their own genome
and perform many essential functions in eukaryotic cells, including ATP synthesis via …

The discovery that mutations in mitochondrial DNA (mtDNA) can be pathogenic in humans
has increased interest in understanding mtDNA maintenance. The functional state of mtDNA …

Infertility is defined as a failure to conceive in a couple trying to reproduce for a period of two
years without conception. Approximately 15 percent of couples are infertile, and among …

Progressive external ophthalmoplegias (PEO) characterized by accumulation of large-scale
mitochondrial DNA (mtDNA) deletions are rare human diseases. We mapped a new locus …

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

We here reconstitute a minimal mammalian mitochondrial DNA (mtDNA) replisome in vitro.
The mtDNA polymerase (POLγ) cannot use double‐stranded DNA (dsDNA) as template for …

OBJECTIVE: To determine the content of mitochondrial DNA (mtDNA) in oocytes from a
range of patients with fertilization success and failure. DESIGN: Analysis of mtDNA content …

As regulators of bioenergetics in the cell and the primary source of endogenous reactive
oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the …