Detection of mismatched human leukocyte antigens by adaptive immune cells is considered
as the main cause of transplant rejection, leading to either T-cell mediated rejection or …

Abstract Although anti–HLA (Human Leukocyte Antigen) donor-specific antibodies (DSAs)
are commonly measured in clinical practice and their relationship with transplant outcome is …

Background The relationship between the donor-derived cell-free DNA fraction (dd-cfDNA
[%]) in plasma in kidney transplant recipients at time of indication biopsy and gene …

Abstract The XVI-th Banff Meeting for Allograft Pathology was held at Banff, Alberta, Canada,
from 19th to 23rd September 2022, as a joint meeting with the Canadian Society of …

Rejection remains the main cause of premature graft loss after kidney transplantation,
despite the use of potent immunosuppression. This highlights the need to better understand …

We studied the clinical, histologic, and molecular features distinguishing DSA-negative from
DSA-positive molecularly defined antibody-mediated rejection (mABMR). We analyzed …

Background Circulating anti-HLA donor-specific antibodies (HLA-DSA) are often absent in
kidney transplant recipients with microvascular inflammation (MVI). Missing self, the inability …

Background. Trifecta (ClinicalTrials. gov# NCT04239703) is a prospective trial defining
relationships between donor-derived cell-free DNA (dd-cfDNA), donor-specific antibody …

The major medical advances in our knowledge of the human leukocyte antigen (HLA)
system have allowed us to uncover several gaps in our understanding of alloimmunity …

Background The mechanisms regulating CD8+ T cell migration to nonlymphoid tissue
during inflammation have not been fully elucidated, and the migratory properties of effector …