While it is known that a substantial proportion of individuals with tuberculosis disease (TB)
present subclinically, usually defined as bacteriologically-confirmed but negative on …

Background Thirty countries with the highest tuberculosis (TB) burden bear 87% of the
world's TB cases. Delayed diagnosis and treatment are detrimental to TB prognosis and …

Background Prevalence surveys show a substantial burden of subclinical (asymptomatic but
infectious) tuberculosis, from which individuals can progress, regress, or even persist in a …

Background Whole genome sequencing provides better delineation of transmission clusters
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …

Background: Individuals with bacteriologically confirmed pulmonary tuberculosis (TB)
disease who do not report symptoms (subclinical TB) represent around half of all prevalent …

Case fatality rates for tuberculosis disease (TB) have fallen progressively over the past 20
years, and an estimated 54 million people have survived TB since 2000. 1 More recently …

There is growing recognition that tuberculosis (TB) infection and disease exists as a
spectrum of states beyond the current binary classification of latent and active TB. Our aim …

Tuberculosis (TB) remains a major global threat and diagnosis of active TB ((ATB) both extra-
pulmonary (EPTB), pulmonary (PTB)) and latent TB (LTBI) infection remains challenging …

Traditional understanding of the risk of progression from Mycobacterium tuberculosis (Mtb)
infection to tuberculosis (TB) overlooks diverse presentations across a spectrum of disease …

Active case-finding (ACF) is an important component of the End TB Strategy. However, ACF
is resource-intensive, and the economics of ACF are not well-understood. Data on the costs …