Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

With the continuing trend to study larger and more complex systems, the application of
protein cross-linking coupled with mass spectrometry (XL-MS) provides a varied toolkit …

Mass spectrometry (MS) plays a central role in studies on protein structure and dynamics.
This review highlights some of the recent developments in this area, with focus on …

In recent years, RNA has emerged as a multifaceted biomolecule that is involved in virtually
every function of the cell and is critical for human health. This has led to a substantial …

It has been 20 years since the publication of Chemistry of Protein Conjugation and Cross-
Linking. During this period, great advances have been made in the area of cross-linking of …

RNA molecules are master regulators of cells. They are involved in a variety of molecular
processes: they transmit genetic information, sense cellular signals and communicate …

Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) have
revolutionized the field of nucleic acid analysis. These soft ionization techniques facilitate …

The gas phase structures of the deprotonated 2′-deoxymononucleotides including 2′-
deoxyadenosine-5′-monophosphate (dA5′ p), 2′-deoxycytidine-5′-monophosphate …

In addition to mRNAs whose primary function is transmission of genetic information from
DNA to proteins, numerous other classes of RNA molecules exist, which are involved in a …

Ultraviolet photodissociation (UVPD) at 193 nm is compared to collision induced
dissociation (CID) for sequencing and determination of modifications of multideprotonated …