Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and
metaplasia result in changes in stored and secreted mucin and the production of a …

Airway mucus obstruction is a hallmark of many chronic lung diseases including rare genetic
disorders such as cystic fibrosis (CF) and primary ciliary dyskinesia, as well as common lung …

We used 3D cell printing to emulate an airway coupled with a naturally-derived blood vessel
network in vitro. Decellularized extracellular matrix bioink derived from porcine tracheal …

The airway epithelium comprises of different cell types and acts as a physical barrier
preventing pathogens, including inhaled particles and microbes, from entering the lungs …

The ocular surface including the cornea and conjunctiva and its overlying tear film are the
first tissues of the eye to interact with the external environment. The tear film is complex …

Recent evidence suggests that the airway mucus gel layer may be impermeable to the viral
and synthetic gene vectors used in past inhaled gene therapy clinical trials for diseases like …

Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate
airway clearance by mucociliary transport. In cystic fibrosis (CF) altered mucus properties …

Airway mucus constitutes a thin layer of airway surface liquid with component
macromolecules that covers the luminal surface of the respiratory tract. The major function of …

Quercetin is a plant-derived flavonoid widely known by its anti-oxidant and anti-inflammatory
properties, but its oral bioavailability is very poor and this becomes difficult to assess its …