YB‐1 protein: functions and regulation

DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …

Y-box-binding protein 1 (YB-1) and its functions

IA Eliseeva, ER Kim, SG Guryanov… - Biochemistry …, 2011 - Springer
This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

Loss of super-enhancer-regulated circRNA Nfix induces cardiac regeneration after myocardial infarction in adult mice

S Huang, X Li, H Zheng, X Si, B Li, G Wei, C Li… - Circulation, 2019 - Am Heart Assoc
Background: circRNAs (circular RNAs) are emerging as powerful regulators of cardiac
development and disease, but their roles in cardiac regeneration are still unknown. This …

LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell …

Y Ban, P Tan, J Cai, J Li, M Hu, Y Zhou… - Molecular …, 2020 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) constitute approximately 4% of all
cancers worldwide. In this study, we analyzed the expression profile of the long noncoding …

Cold shock proteins: from cellular mechanisms to pathophysiology and disease

JA Lindquist, PR Mertens - Cell Communication and Signaling, 2018 - Springer
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …

Protein interaction mapping identifies RBBP6 as a negative regulator of Ebola virus replication

J Batra, JF Hultquist, D Liu, O Shtanko, J Von Dollen… - Cell, 2018 - cell.com
Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about
how EBOV usurps host pathways during infection. To address this, we used affinity tag …

YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

Proteasome system of protein degradation and processing

AV Sorokin, ER Kim, LP Ovchinnikov - Biochemistry (Moscow), 2009 - Springer
In eukaryotic cells, degradation of most intracellular proteins is realized by proteasomes.
The substrates for proteolysis are selected by the fact that the gate to the proteolytic chamber …

The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives

Y Chen, Z Jiang, Y Yang, C Zhang, H Liu… - International Journal of …, 2023 - Elsevier
RNA methylation, an epigenetic modification that does not alter gene sequence, may be
important to diverse biological processes. Protein regulators of RNA methylation include …

SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1

W Gao, L Chen, L Lin, M Yang, T Li, H Wei, C Sha… - Oncogenesis, 2022 - nature.com
Chemoresistance is a severe outcome among patients with epithelial ovarian cancer (EOC)
that leads to a poor prognosis. YBX-1 has been shown to cause treatment failure and cancer …