Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Human pluripotent stem (hPS) cells can, in theory, be differentiated into any cell type,
making them a powerful in vitro model for human biology. Recent technological advances …

Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

Age-related macular degeneration (AMD) and related macular dystrophies (MDs) primarily
affect the retinal pigment epithelium (RPE) in the eye. A hallmark of AMD/MDs that drives …

Age-related macular degeneration (AMD) is the leading cause of blindness in individuals
over the age of 50 years, yet its etiology and pathogenesis largely remain uncovered. Single …

Purpose To identify age-related macular degeneration (AMD) risk loci and to establish a
polygenic prediction model. Design Genome-wide association study (GWAS) and polygenic …

Blindness poses a growing global challenge, with approximately 26% of cases attributed to
degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive …

Age‐related macular degeneration (AMD), the leading cause of blindness in elderly
populations, involves the loss of central vision due to progressive dysfunction of the retinal …

Some human retinal diseases are characterized by pathology that is restricted to specific cell
types and to specific regions of the eye. Several disease entities either selectively affect or …