Antibacterial drug discovery in the resistance era

ED Brown, GD Wright - Nature, 2016 - nature.com
The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

[HTML][HTML] New agents for the treatment of drug-resistant Mycobacterium tuberculosis

DT Hoagland, J Liu, RB Lee, RE Lee - Advanced drug delivery reviews, 2016 - Elsevier
Inadequate dosing and incomplete treatment regimens, coupled with the ability of the
tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have …

Quinoline: a promising antitubercular target

RS Keri, SA Patil - Biomedicine & Pharmacotherapy, 2014 - Elsevier
Tuberculosis (TB) remains a global public health problem in recent years. TB originated
mainly from various strains of Mycobacterium tuberculosis, is a highly infectious and chronic …

Determinants of bacterial morphology: from fundamentals to possibilities for antimicrobial targeting

MCF van Teeseling, MA de Pedro, F Cava - Frontiers in microbiology, 2017 - frontiersin.org
Bacterial morphology is extremely diverse. Specific shapes are the consequence of adaptive
pressures optimizing bacterial fitness. Shape affects critical biological functions, including …

Triazole: a promising antitubercular agent

RS Keri, SA Patil, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The
statistics shows that around three million people throughout the world die annually from …

New strategies for combating multidrug-resistant bacteria

GD Wright, AD Sutherland - Trends in molecular medicine, 2007 - cell.com
Antibiotic resistance is a problem that continues to challenge the healthcare sector. In
particular, multidrug resistance is now common in familiar pathogens such as …

Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ–a structural insight to unveil antibacterial activity of curcumin

S Kaur, NH Modi, D Panda, N Roy - European journal of medicinal …, 2010 - Elsevier
The cytoskeletal protein, FtsZ plays a pivotal role in prokaryotic cell division and is present in
majority of the bacterial species. In recent years, inhibitors of FtsZ have been identified that …

[HTML][HTML] A review on quinoline hydrazone derivatives as a new class of potent antitubercular and anticancer agents

MC Mandewale, UC Patil, SV Shedge… - Beni-Suef University …, 2017 - Elsevier
Tuberculosis (TB) and Cancer remains a global public health problem in recent years. There
is an urgent need for the screening of new bioactive molecules with new targets and with a …

Structure-based discovery of substituted 4, 5′-bithiazoles as novel DNA gyrase inhibitors

M Brvar, A Perdih, M Renko, G Anderluh… - Journal of medicinal …, 2012 - ACS Publications
Bacterial DNA gyrase is a well-established and validated target for the development of novel
antibacterials. Starting from the available structural information about the binding of the …

Recent advances in the chemistry and biology of naturally occurring antibiotics

KC Nicolaou, JS Chen, DJ Edmonds… - Angewandte Chemie …, 2009 - Wiley Online Library
Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …