The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans,
secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such …

Endothelium, the gatekeeper of our blood vessels, is highly heterogeneous and a crucial
physical barrier with the ability to produce vasoactive and protective mediators under …

Background Despite differences in time of sepsis recognition, recent studies support that
early initiation of norepinephrine in patients with septic shock (SS) improves outcome …

Sepsis is a complex disease due to dysregulated host response to infection. Oxidative stress
and mitochondrial dysfunction leading to metabolic dysregulation are among the hallmarks …

Purpose Sepsis is a life-threatening organ dysfunction. It is caused by a dysregulated
immune response to an infection and is one of the leading causes of death in the intensive …

Objectives The early identification of septic shock patients at high risk of poor outcome is
essential to early initiate optimal treatments and to decide on hospital admission …

Introduction Microcirculatory alterations are key mechanisms in sepsis pathophysiology
leading to tissue hypoxia, edema formation, and organ dysfunction. Hyperspectral imaging …

Optimal management of cardiogenic shock requiring extracorporeal membrane oxygenation
(ECMO) is still an evolving area in which assessment and optimization of the …

Background Septic shock is the development of sepsis to refractory circulatory collapse and
metabolic derangements, characterized by persistent hypotension and increased lactate …

The early identification of microvascular changes in patients with Coronavirus Disease 2019
(COVID-19) may offer an important clinical opportunity. This study aimed to define a method …