Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Although systemic hypertension affects a large proportion of the population, its etiology
remains poorly defined. Emerging evidence supports the concept that immune cells become …

Atherosclerosis is the most common form of vascular disease and constitutes the major
cause of death, with 17.5 million related deaths annually (31% of global mortality). 1 …

Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Located in the innermost layer of the vasculature and directly interacting with blood flow,
endothelium integrates various biochemical and biomechanical signals to maintain barrier …

Epithelial monolayers are one-cell-thick tissue sheets that line most of the body surfaces,
separating internal and external environments. As part of their function, they must withstand …

Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins
leading to progressive thickening of the submesothelial compact zone of the peritoneal …

Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …