mRNA-based cancer therapeutics
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …
treatments in a shorter time frame and with reduced expense compared to conventional …
m6A RNA methylation: from mechanisms to therapeutic potential
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
Exon architecture controls mRNA m6A suppression and gene expression
N 6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
Exon junction complex shapes the m6A epitranscriptome
Abstract N6-methyladenosine (m6A), the most abundant modification of mRNA, is essential
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
Dynamic regulation and functions of mRNA m6A modification
S Wang, W Lv, T Li, S Zhang, H Wang, X Li… - Cancer cell …, 2022 - Springer
Abstract N 6-Methyladenosine (m6A), the most abundant internal modification associated
with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the …
with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the …
[HTML][HTML] Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation
RL Kan, J Chen, T Sallam - Trends in Genetics, 2022 - cell.com
Epigenetic modifications occur on genomic DNA and histones to influence gene expression.
More recently, the discovery that mRNA undergoes similar chemical modifications that …
More recently, the discovery that mRNA undergoes similar chemical modifications that …
[HTML][HTML] The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
L Ma, T Chen, X Zhang, Y Miao, X Tian, K Yu, X Xu… - Redox Biology, 2021 - Elsevier
The biological functions of N6-methyladenosine (m 6 A) RNA methylation are mainly
dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we …
dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we …
Genetic drivers of m6A methylation in human brain, lung, heart and muscle
The most prevalent post-transcriptional mRNA modification, N 6-methyladenosine (m6A),
plays diverse RNA-regulatory roles, but its genetic control in human tissues remains …
plays diverse RNA-regulatory roles, but its genetic control in human tissues remains …