HuR and mRNA stability

CM Brennan, JA Steitz* - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression

B Carpenter, C MacKay, A Alnabulsi, M MacKay… - … et Biophysica Acta (BBA …, 2006 - Elsevier
The heterogeneous nuclear ribonucleoproteins (hnRNP) are a family of proteins which
share common structural domains, and extensive research has shown that they have central …

A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy

WW Du, W Yang, X Li, FM Awan, Z Yang, L Fang, J Lyu… - Oncogene, 2018 - nature.com
Circular RNAs are a large group of noncoding RNAs that are widely expressed in
mammalian cells. Genome-wide analyses have revealed abundant and evolutionarily …

[HTML][HTML] Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs

XC Fan, JA Steitz - The EMBO journal, 1998 - embopress.org
The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

HuR binding to cytoplasmic mRNA is perturbed by heat shock

IE Gallouzi, CM Brennan… - Proceedings of the …, 2000 - National Acad Sciences
AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding
many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a …

G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, A role for GG pairing in immunoglobulin switch recombination

LA Dempsey, H Sun, LA Hanakahi, N Maizels - Journal of Biological …, 1999 - ASBMB
The immunoglobulin heavy chain switch regions contain multiple runs of guanines on the
top (nontemplate) DNA strand. Here we show that LR1, a B cell-specific, duplex DNA …

Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation

B Liao, Y Hu, G Brewer - Nature structural & molecular biology, 2007 - nature.com
Abstract (A+ U)-rich elements (AREs) within 3′ untranslated regions are signals for rapid
degradation of messenger RNAs encoding many oncoproteins and cytokines. The ARE …

[图书][B] Gene sharing and evolution: the diversity of protein functions

J Piatigorsky - 2007 - degruyter.com
This book explores gene sharing—a term originally coined to describe the observation that
structural proteins (called crystallins) responsible for the transparent and refractive …

Versatile role for hnRNP D isoforms in the differential regulation of cytoplasmic mRNA turnover

N Xu, CYA Chen, AB Shyu - Molecular and cellular biology, 2001 - Am Soc Microbiol
An important emerging theme is that heterogeneous nuclear ribonucleoproteins (hnRNPs)
not only function in the nucleus but also control the fates of mRNAs in the cytoplasm. Here …

Nuclear import and export functions in the different isoforms of the AUF1/heterogeneous nuclear ribonucleoprotein protein family

B Sarkar, JY Lu, RJ Schneider - Journal of Biological Chemistry, 2003 - ASBMB
The heterogeneous nuclear ribonucleoprotein D family of proteins also known as AUF1
consists of four isoforms implicated in both nuclear and cytoplasmic functions. The AUF1 …