Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain
tissue homeostasis and regeneration of lost body parts in planarians. However, the lack of …

Regeneration requires the coordination of stem cells, their progeny and distant differentiated
tissues. Here, we present a comprehensive atlas of whole-body regeneration in Schmidtea …

Regeneration requires mechanisms for producing a wide array of cell types. Neoblasts are
stem cells in the planarian Schmidtea mediterranea that undergo fate specification to …

Whole-body regeneration of planarians is a natural wonder but how it occurs remains
elusive. It requires coordinated responses from each cell in the remaining tissue with spatial …

The majority of animal phyla have species that can regenerate. Comparing regeneration
across animals can reconstruct the molecular and cellular evolutionary history of this …

Abstract Background The planarian Schmidtea mediterranea is a master regenerator with a
large adult stem cell compartment. The lack of transgenic labeling techniques in this animal …

The interrelationship between endogenous microbiota, the immune system, and tissue
regeneration is an area of intense research due to its potential therapeutic applications. We …