Many therapeutic antibodies deplete target cells and elicit immunotherapy by engaging
activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are …

Background Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to
altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the …

The B-cell receptor (BCR) is a key player of the adaptive immune system. It is a unique part
of immunoglobulin (Ig) molecules expressed on the surface of B cells. In case of many B-cell …

While T-cell-mediated immune responses in solid tumors have been well-established and
have driven major therapeutic advances, our understanding of B-cell biology in cancer is …

To assess the safety and tolerability of NVS32b, a monoclonal, afucosylated, anti-CD32b
(FCGR2B) antibody, we used a humanized transgenic (Tg) mouse model that expresses all …