[HTML][HTML] Early-stage non-small cell lung cancer: New challenges with immune checkpoint blockers and targeted therapies

P Lavaud, M Bortolot, L Zullo, D O'Reilly, J Naidoo… - Cancers, 2024 - mdpi.com
Simple Summary The current review summarizes the new potential treatment strategies for
patients with early-stage non-small cell lung cancer with immunotherapy and targeted …

Revolutionizing Localized Lung Cancer Treatment: Neoadjuvant Chemotherapy plus Immunotherapy for All?

V Ferrari, C Helissey - Journal of Clinical Medicine, 2024 - mdpi.com
Lung cancer poses a significant public health challenge, with resectable non-small cell lung
cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA …

SOX4-BMI1 axis promotes non-small cell lung cancer progression and facilitates angiogenesis by suppressing ZNF24

T Wen, X Zhang, Y Gao, H Tian, L Fan, P Yang - Cell Death & Disease, 2024 - nature.com
The incidence of lung cancer has become the highest among all cancer types globally, also
standing as a leading cause of cancer-related deaths. Lung cancer is broadly divided into …

[HTML][HTML] Fluorofenidone enhances cisplatin efficacy in non-small cell lung cancer: a novel approach to inhibiting cancer progression

S Wang, G Liu, L Yu, C Zhang… - Translational Lung …, 2024 - pmc.ncbi.nlm.nih.gov
Background Non-small cell lung cancer (NSCLC), the most prevalent lung cancer subtype,
presents significant treatment challenges. Cisplatin (CP)-based regimens are central to the …

Surgical and safety outcomes in patients with non-small cell lung cancer receiving neoadjuvant chemoimmunotherapy versus chemotherapy alone: A systematic …

R Aburaki, Y Fujiwara, K Chida, N Horita… - Cancer treatment …, 2024 - Elsevier
Neoadjuvant immune checkpoint blockade (ICB) combined with chemotherapy has
improved survival outcomes in locally-advanced non-small cell lung cancer (NSCLC) …

Meta-Analysis Methods for Neoadjuvant Chemoimmunotherapy for Non–Small Cell Lung Cancer

L Zhang, J Li, L Guo - JAMA oncology, 2024 - jamanetwork.com
Results| Of 834 797 patients (53.0% male; median [IQR] age, 66 [56-76] years; race and
ethnicity, 3.7% Asian; 11.9% Black; 6.6% Hispanic; 0.6% Native and Pacific Islander; 81.8 …

Outcomes After Neoadjuvant Therapy With or Without Immunotherapy Followed By Pneumonectomy in Non-Small Cell Lung Cancer Patients

Z Li, L Wu, C Wang, S Wang, Q Chen, W He - The Annals of Thoracic …, 2024 - Elsevier
Background There are limited data concerning pneumonectomy after preoperative induction
therapy. Our study aimed to evaluate feasibility and safety of pneumonectomy after …

Exploring clinical factors to predict the survival of patients with resectable non-small cell lung cancer with neoadjuvant immunotherapy

M Zhang, M Yan, Z Xiao, Y Li, Z Liu… - European Journal of …, 2024 - academic.oup.com
OBJECTIVES The goal was to explore clinical factors and build a predictive model for the
disease-free and overall survival of patients with non-small cell lung cancer (NSCLC) …

[HTML][HTML] A novel small molecule NJH-13 induces pyroptosis via the Ca2+ driven AKT-FOXO1-GSDME signaling pathway in NSCLC by targeting TRPV5

X Dong, J Nie, A Huang, L Chen, E Zang… - Journal of Advanced …, 2025 - Elsevier
Introduction Pyroptosis represents a mode of programmed necrotic cell death (PCD),
mediated by members of gasdermin family (GSDMs), such as GSDME. It is emerging as a …

[HTML][HTML] Evidence for the evolving role of neoadjuvant and perioperative immunotherapy in resectable non-small cell lung cancer

T Hansen, J Hill, G Tincknell, D Siu… - … of Targeted Anti …, 2024 - pmc.ncbi.nlm.nih.gov
The treatment of early-stage non-small cell lung cancer (NSCLC) is becoming increasingly
complex. Standard of care management for the past decade has been adjuvant …