Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

The existence of a sex gap in human health and longevity has been widely documented.
Autosomal DNA methylation differences between males and females have been reported …

The decline of brain function during aging is associated with epigenetic changes, including
DNA methylation. Lifestyle interventions can improve brain function during aging, but their …

Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

Gene expression in the aging brain depends on transcription signals generated by
senescent physiology, interacting with genetic and epigenetic programs. In turn …

Cancer is an aging‐associated disease, but the underlying molecular links between these
processes are still largely unknown. Gene promoters that become hypermethylated in aging …

Aging is associated with a progressive decline of brain function, and the underlying causes
and possible interventions to prevent this cognitive decline have been the focus of intense …