ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and
the Prevention of Sudden Cardiac Death: A Report of the American College of …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …

First introduced as a new clinical entity in 1992, the Brugada syndrome is associated with a
relatively high risk of sudden death in young adults, and occasionally in children and infants …

BS; 22 MOG123 (mutations in this gene cause INa reduction by impairing the trafficking of
the cardiac Na+ channel to the cell membrane); KCNE524 and KCND325 (mutations in both …

Cardiac sodium channel dysfunction caused by mutations in the SCN5A gene is associated
with a number of relatively uncommon arrhythmia syndromes, including long-QT syndrome …

Abstract Objective: Brugada syndrome (BrS) is characterized by ventricular tachyarrhythmias
leading to sudden cardiac death and is caused, in part, by mutations in the SCN5A gene …

Introduction: The clinical phenotype is 8 to 10 times more prevalent in males than in females
in patients with Brugada syndrome. Brugada syndrome has been reported to be thinner than …

Aims Fluctuations between the diagnostic ECG pattern and non-diagnostic ECGs in patients
with Brugada syndrome are known, but systematic studies are lacking. The purpose of this …

Voltage-gated Na+ channels mediate the rapid upstroke of the action potential in excitable
tissues. Nav1. 5, encoded by the SCN5A gene, is the predominant isoform in the heart …

Risk stratification in Brugada syndrome remains a clinical challenge because the event rate
is low but the presenting symptom is often cardiac arrest (CA). We review the data on risk …