Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Cerebellar cortical organization: a one-map hypothesis

R Apps, R Hawkes - Nature Reviews Neuroscience, 2009 - nature.com
The fundamental architecture of the cerebellum is concealed within a terminological forest—
transverse zones and stripes, longitudinal zones and microzones, patches, etc. To make …

Motor learning and the cerebellum

CI De Zeeuw, MM Ten Brinke - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Although our ability to store semantic declarative information can nowadays be readily
surpassed by that of simple personal computers, our ability to learn and express procedural …

Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum

RV Sillitoe, AL Joyner - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
The most noticeable morphological feature of the cerebellum is its folded appearance,
whereby fissures separate its anterior-posterior extent into lobules. Each lobule is …

Purkinje cell microzones mediate distinct kinematics of a single movement

FGC Blot, JJ White, A van Hattem, L Scotti… - nature …, 2023 - nature.com
The classification of neuronal subpopulations has significantly advanced, yet its relevance
for behavior remains unclear. The highly organized flocculus of the cerebellum, known to …

Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning

P Wulff, M Schonewille, M Renzi, L Viltono… - Nature …, 2009 - nature.com
Although feedforward inhibition onto Purkinje cells was first documented 40 years ago, we
understand little of how inhibitory interneurons contribute to cerebellar function in behaving …

Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage

K Beppu, T Sasaki, KF Tanaka, A Yamanaka… - Neuron, 2014 - cell.com
The brain demands high-energy supply and obstruction of blood flow causes rapid
deterioration of the healthiness of brain cells. Two major events occur upon ischemia …

Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation

T Sasaki, K Beppu, KF Tanaka… - Proceedings of the …, 2012 - National Acad Sciences
Dynamic activity of glia has repeatedly been demonstrated, but if such activity is
independent from neuronal activity, glia would not have any role in the information …

Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning

H Hoang, S Tsutsumi, M Matsuzaki, M Kano, M Kawato… - Elife, 2023 - elifesciences.org
Cerebellar climbing fibers convey diverse signals, but how they are organized in the
compartmental structure of the cerebellar cortex during learning remains largely unclear. We …

Climbing fiber input shapes reciprocity of Purkinje cell firing

A Badura, M Schonewille, K Voges, E Galliano… - Neuron, 2013 - cell.com
The cerebellum fine-tunes motor activity via its Purkinje cell output. Purkinje cells produce
two different types of spikes, complex spikes and simple spikes, which often show reciprocal …