Introduction: Cannabidiol (CBD) as Epidiolex®(GW Pharmaceuticals) was recently
approved by the US Food and Drug Administration (FDA) to treat rare forms of epilepsy in …

Significance: Redox imbalance may lead to overproduction of reactive oxygen and nitrogen
species (ROS/RNS) and subsequent oxidative tissue damage, which is a critical event in the …

With the proposed Canadian July 2018 legalization of marijuana through the Cannabis Act,
a thorough critical analysis of the current trials on the efficacy of medicinal marijuana (MM) …

Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid with anti-inflammatory activity
mediated by enhancing adenosine signaling. As the adenosine A1 receptor activation …

With the increase of life expectancy, neurodegenerative disorders are becoming not only a
health but also a social burden worldwide. However, due to the multitude of …

Background: Spasticity continues to be a very prevalent, highly invalidating, and difficult-to-
manage symptom in patients with multiple sclerosis (MS). The aim of this systematic review …

Marijuana use for medical purposes dates back to ancient times. Despite its high therapeutic
potential, its adverse effects have raised important legal restrictions. However, this situation …

Key points Marijuana was found to cause muscle weakness, although the exact regulatory
role of its receptors (CB1 cannabinoid receptor; CB1R) in the excitation–contraction …

There are numerous reports that people with multiple sclerosis (MS) have for many years
been self-medicating with illegal street cannabis or more recently medicinal cannabis to …

Effective symptomatic management of multiple sclerosis (MS) spasticity remains an unmet
need for many patients. The second-line option nabiximols is the most widely investigated of …