The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …

Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Persistent changes in tree mortality rates can alter forest structure, composition, and
ecosystem services such as carbon sequestration. Our analyses of longitudinal data from …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Diverse membrane fusion reactions in biology involve close contact between two lipid
bilayers, followed by the local distortion of the individual bilayers and reformation into a …

Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon
Ca 2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes …

Membrane fusion can occur between cells, between different intracellular compartments,
between intracellular compartments and the plasma membrane and between lipid-bound …

Establishment and maintenance of proper architecture is essential for endoplasmic
reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and …

Neurotransmitter release at synapses involves a highly specialized form of membrane fusion
that is triggered by Ca2+ ions and is optimized for speed. These observations were …

The core of the neurotransmitter release machinery is formed by SNARE complexes, which
bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1 …