Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

Lengthy multidrug chemotherapy is required to achieve a durable cure in tuberculosis.
However, we lack well-validated, high-throughput in vitro models that predict animal …

Mycobacterium tuberculosis can survive within its host for extended periods of time without
any clinical symptoms of disease and reactivate when the immune system is weakened. A …

Despite the existence of well-characterized, canonical mutations that confer high-level drug
resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance …

While most bacterial species taken up by macrophages are degraded through processing of
the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway …

Mycobacterium tuberculosis, the causative agent of tuberculosis, is a growing threat to
global health, with recent efforts towards its eradication being reversed in the wake of the …

Both latent and active TB infections are caused by a heterogeneous population of
mycobacteria, which includes actively replicating and dormant bacilli in different proportions …

Through long-term interactions with their hosts, bacterial pathogens have evolved unique
arsenals of effector proteins that interact with specific host targets and reprogram the host …

As the goal of a bacterium is to become bacteria, evolution has imposed continued
selections for gene expression. The intracellular pathogen Mycobacterium tuberculosis, the …