Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

Successful regeneration of critical-size defects remains one of the significant challenges in
regenerative engineering. These large-scale bone defects are difficult to regenerate and are …

In this study, we present the photosynthetic oxygen (O 2) supply to mammalian cells within a
volumetric extracellular matrix-like construct, whereby a three-dimensional (3D)-bioprinted …

The effect of a reduced deuterium (D) content in the incubation medium on the survival of
cultured neurons in vitro and under glucose deprivation was studied. In addition, we studied …

Heart failure is the leading cause of death worldwide. The inability of the adult mammalian
heart to regenerate following injury results in the development of systolic heart failure. Thus …

Introduction Embryo and fetus grow and mature over the first trimester of pregnancy in a
dynamic hypoxic environment, where placenta development assures an increased oxygen …

Simple Summary Early embryo development is a dynamic and orchestrated event. Oxygen
plays a fundamental role in several key biological processes necessary to sustain and …

Significance: The geological record shows that as atmospheric O2 levels increased, it
concomitantly coincided with the evolution of metazoans. More complex, higher organisms …

The limited availability of transplantable organs hinders the success of patient treatment
through organ transplantation. In addition, there are challenges with immune rejection and …

The precise positioning and arrangement of cell spheroids and organoids are critical to
reconstructing complex tissue architecture for tissue engineering and regenerative …