Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application

Z Ma, N Wang, H He, X Tang - Journal of Controlled Release, 2019 - Elsevier
Curcumin (Cur), a natural compound from Curcuma longa Linn, has various of
pharmacological activities such as anti-cancer, anti-inflammatory, anti-oxidant, anti …

Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility

A Araiza-Calahorra, M Akhtar, A Sarkar - Trends in Food Science & …, 2018 - Elsevier
Background Curcumin has been widely acknowledged for its health-promoting effects.
However, its application is often limited by its poor water solubility and biochemical/structural …

Enhanced drug delivery by dissolution of amorphous drug encapsulated in a water unstable metal–organic framework (MOF)

K Suresh, AJ Matzger - Angewandte Chemie International …, 2019 - Wiley Online Library
Encapsulating a drug molecule into a water‐reactive metal–organic framework (MOF) leads
to amorphous drug confined within the nanoscale pores. Rapid release of drug occurs upon …

[HTML][HTML] Novel chitosan/γ-alumina/carbon quantum dot hydrogel nanocarrier for targeted drug delivery

MH Karami, M Pourmadadi, M Abdouss… - International Journal of …, 2023 - Elsevier
Curcumin (CUR) is among the most natural and effective antitumor drugs for cancer
treatment. These drugs have low solubility and short half-lives that reduce their effectiveness …

Solubility advantage of amorphous drugs and pharmaceutical cocrystals

NJ Babu, A Nangia - Crystal Growth & Design, 2011 - ACS Publications
The current phase of drug development is witnessing an oncoming crisis due to the
combined effects of increasing R&D costs, decreasing number of new drug molecules being …

Curcumin

MLAD Lestari, G Indrayanto - Profiles of drug substances, excipients and …, 2014 - Elsevier
Curcumin and its two related compounds, that is, demethoxycurcumin and bis-
demethoxycurcumin (curcuminoids) are the main secondary metabolites of Curcuma longa …

Water soluble complexes of curcumin with cyclodextrins: Characterization by FT-Raman spectroscopy

PRK Mohan, G Sreelakshmi, CV Muraleedharan… - Vibrational …, 2012 - Elsevier
Many recent reports on curcumin, a polyphenol from Curcuma longa, provide mounting
evidence on the pharmacological activity of this natural product. However, the …

Engineering cocrystals of poorly water-soluble drugs to enhance dissolution in aqueous medium

I Sathisaran, SV Dalvi - Pharmaceutics, 2018 - mdpi.com
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Methods to improve the solubility of curcumin from turmeric

J Górnicka, M Mika, O Wróblewska, P Siudem… - Life, 2023 - mdpi.com
Turmeric is a strong-taste component of spices characteristic of Indian cuisine. It is obtained
from the turmeric rhizome (Curcumae longae rhizoma) and has been used for thousands of …

Naturally-derived targeted therapy for wound healing: Beyond classical strategies

S El-Ashram, LM El-Samad, AA Basha… - Pharmacological …, 2021 - Elsevier
This review summarizes the four processes of wound healing in the human body
(hemostasis, inflammatory, proliferation, and remodeling) and the most current research on …