Nodal-related ligands of the transforming growth factor-beta (TGFβ) superfamily play central
roles in patterning the early embryo during the induction of mesoderm and endoderm and …

Although the left and right hemispheres of our brains develop with a high degree of
symmetry at both the anatomical and functional levels, it has become clear that subtle …

Left-right asymmetries in brains are usually minor or cryptic. We report brain asymmetries in
the tiny, dorsal tubular nervous system of the ascidian tadpole larva, Ciona intestinalis …

TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

We have compared the dorsoventral development of hemichordates and chordates to
deduce the organization of their common ancestor, and hence to identify the evolutionary …

In many systems, ion flows and long-term endogenous voltage gradients regulate patterning
events, but molecular details remain mysterious. To establish a mechanistic link between …

Many animals display specific internal or external features with left–right asymmetry. In
vertebrates, the molecular pathway that leads to this asymmetry uses the signalling …

Morphological asymmetry is a common feature of animal body plans, from shell coiling in
snails to organ placement in humans. The signaling protein Nodal is key for determining this …

Sea urchins are emblematic models in developmental biology and display several
characteristics that set them apart from other deuterostomes. To uncover the genomic cues …

Determination of the vertebrate left-right body axis during embryogenesis results in
asymmetric development and placement of most inner organs [1, 2]. Although the …