Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Telomerase plays a critical role in stem cell function and tissue regeneration that depends
on its ability to elongate telomeres. For nearly two decades, it turned out that TERT regulates …

Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans.
In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal …

Objective We investigated the relationship between diabetes and telomere length by meta-
analysis. Methods We searched five popular databases for articles published between 1990 …

Abstract Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting
protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ), plays …

Telomerase plays a pivotal role in bypassing cellular senescence and maintaining telomere
homeostasis, essential properties required for the sustenance and progression of cancer …

Coronary heart disease is one of the main causes of death in the developed world, and
treatment success remains modest, with high mortality rates within 1 year after myocardial …

Proper replication of the telomeric DNA at chromosome ends is critical for preserving
genome integrity. Yet, telomeres present challenges for the replication machinery, such as …

Human shelterin is a six-subunit complex—composed of TRF1, TRF2, Rap1, TIN2, TPP1,
and POT1—that binds telomeres, protects them from the DNA-damage response, and …

Telomere maintenance is essential for maintaining genome integrity in both normal and
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …