Evaluating pain behaviours: Widely used mechanical and thermal methods in rodents

AD Modi, A Parekh, YN Pancholi - Behavioural Brain Research, 2023 - Elsevier
Globally, over 300 million surgical procedures are performed annually, with pain being one
of the most common post-operative side effects. During the onset of injury, acute pain plays …

Porcine spinal cord injury model for translational research across multiple functional systems

RU Ahmed, CA Knibbe, F Wilkins, LC Sherwood… - Experimental …, 2023 - Elsevier
Animal models are necessary to identify pathological changes and help assess therapeutic
outcomes following spinal cord injury (SCI). Small animal models offer value in research in …

Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis

W Zhou, M Silva, C Feng, S Zhao, L Liu, S Li… - Stem cell research & …, 2021 - Springer
Background Spinal cord injury (SCI) is a debilitating medical condition that can result in the
irreversible loss of sensorimotor function. Current therapies fail to provide an effective …

Human epidural AD–MSC exosomes improve function recovery after spinal cord injury in rats

SE Sung, MS Seo, YI Kim, KK Kang, JH Choi, S Lee… - Biomedicines, 2022 - mdpi.com
Spinal cord injury (SCI) interferes with the normal function of the autonomic nervous system
by blocking circuits between the sensory and motor nerves. Although many studies focus on …

Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects

FS Bagheri Bavandpouri, A Azizi… - Frontiers in …, 2024 - frontiersin.org
Background Considering the complex pathological mechanisms behind spinal cord injury
(SCI) and the adverse effects of present non-approved drugs against SCI, new studies are …

Injectable hydrogels in stroke and spinal cord injury treatment: a review on hydrogel materials, cell–matrix interactions and glial involvement

PH Lin, Q Dong, SY Chew - Materials Advances, 2021 - pubs.rsc.org
Central nervous system (CNS) pathologies, such as stroke and spinal cord injury, remain
debilitating issues due to the inhibitory environment in the CNS. Many research works have …

Functional rewiring across spinal injuries via biomimetic nanofiber scaffolds

S Usmani, A Franceschi Biagioni… - Proceedings of the …, 2020 - National Acad Sciences
The regrowth of severed axons is fundamental to reestablish motor control after spinal-cord
injury (SCI). Ongoing efforts to promote axonal regeneration after SCI have involved multiple …

Assessment of swim endurance and swim behavior in adult zebrafish

B Burris, N Jensen… - Journal of visualized …, 2021 - pmc.ncbi.nlm.nih.gov
Due to their renowned regenerative capacity, adult zebrafish are a premier vertebrate model
to interrogate mechanisms of innate spinal cord regeneration. Following complete …

[HTML][HTML] The gut-brain axis and beyond: Microbiome control of spinal cord injury pain in humans and rodents

CA Bannerman, K Douchant, PM Sheth… - Neurobiology of Pain, 2021 - Elsevier
Spinal cord injury (SCI) is a devastating injury to the central nervous system in which 60 to
80% of patients experience chronic pain. Unfortunately, this pain is notoriously difficult to …

Intrathecal injection of human placental mesenchymal stem cells derived exosomes significantly improves functional recovery in spinal cord injured rats

A Soleimani, S Oraee Yazdani, M Pedram… - Molecular Biology …, 2024 - Springer
Background Spinal cord injury (SCI) due to lack of restoration of damaged neuronal cells is
associated with sensorimotor impairment. This study was focused on using the human …