In this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced
differentiation of HL-60 cells. The model describes reinforcing feedback between an ATRA …

The zinc finger antiviral protein (ZAP) is an interferon-stimulated gene that restricts the
replication of retroviruses, alphaviruses, and filoviruses. Relatively little is known, however …

Acute promyelocytic leukemia (APL) is a treatment success story. From a highly deadly
disease, it was turned into a highly curable disease by the introduction of differentiation …

Greater understanding of the role of retinoids and their receptors in myeloid cell growth and
differentiation provides important insight into normal myelopoiesis. These findings have …

6-Formylindolo (3, 2-b) carbazole (FICZ) is a photoproduct of tryptophan and an
endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was previously …

Background The aryl hydrocarbon receptor (AhR) ligand 6-Formylindolo (3, 2-b) carbazole
(FICZ) has received increasing attention since its identification as an endogenous AhR …

OBJECTIVE: To investigate the effect of transforming growth factor (TGF)-β1 on the
extracellular signal-regulated kinase (ERK) and Smad pathway and the role of peroxisome …

Differentiation of hair follicle stem cells (HFSCs) into neurons and glial cells represents a
promising cell-based therapy for neurodegenerative diseases. The hair follicle bulge area is …

Although ATRA represents a successful differentiation therapy for APL, it is largely
ineffective for non-APL AMLs. Hence combination therapies using an agent targeting ATRA …

Among the topoisomerase (topo) II isozymes (α and β), topo IIβ has been suggested to
regulate differentiation. In this study, we examined the role of topo IIβ in all-trans retinoic acid …