Ultrasound treatment of neurological diseases—current and emerging applications

G Leinenga, C Langton, R Nisbet, J Goetz - Nature Reviews Neurology, 2016 - nature.com
Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …

Transcranial focused ultrasound (tFUS) and transcranial unfocused ultrasound (tUS) neuromodulation: from theoretical principles to stimulation practices

L Di Biase, E Falato, V Di Lazzaro - Frontiers in neurology, 2019 - frontiersin.org
Transcranial focused ultrasound is an emerging technique for non-invasive
neurostimulation. Compared to magnetic or electric non-invasive brain stimulation, this …

Effective parameters for ultrasound-induced in vivo neurostimulation

RL King, JR Brown, WT Newsome, KB Pauly - Ultrasound in medicine & …, 2013 - Elsevier
Ultrasound-induced neurostimulation has recently gained increasing attention, but little is
known about the mechanisms by which it affects neural activity or about the range of …

3D-printed adaptive acoustic lens as a disruptive technology for transcranial ultrasound therapy using single-element transducers

G Maimbourg, A Houdouin, T Deffieux… - Physics in Medicine …, 2018 - iopscience.iop.org
The development of multi-element arrays for better control of the shape of ultrasonic beams
has opened the way for focusing through highly aberrating media, such as the human skull …

[HTML][HTML] Histologic safety of transcranial focused ultrasound neuromodulation and magnetic resonance acoustic radiation force imaging in rhesus macaques and …

P Gaur, KM Casey, J Kubanek, N Li… - Brain stimulation, 2020 - Elsevier
Background Neuromodulation by transcranial focused ultrasound (FUS) offers the potential
to non-invasively treat specific brain regions, with treatment location verified by magnetic …

Localization of ultrasound-induced in vivo neurostimulation in the mouse model

RL King, JR Brown, KB Pauly - Ultrasound in medicine & biology, 2014 - Elsevier
Developments in the use of ultrasound to stimulate and modulate neural activity have raised
the possibility of using ultrasound as a new investigative and therapeutic tool in brain …

Ultrasound for the brain: a review of physical and engineering principles, and clinical applications

W Qiu, A Bouakaz, EE Konofagou… - IEEE Transactions on …, 2020 - ieeexplore.ieee.org
The emergence of new ultrasound technologies has improved our understanding of the
brain functions and offered new opportunities for the treatment of brain diseases. Ultrasound …

Transcranial ultrasound simulations: A review

C Angla, B Larrat, J Gennisson, S Chatillon - Medical Physics, 2023 - Wiley Online Library
Transcranial ultrasound is more and more used for therapy and imaging of the brain.
However, the skull is a highly attenuating and aberrating medium, with different structures …

A review of numerical and experimental compensation techniques for skull-induced phase aberrations in transcranial focused ultrasound

A Kyriakou, E Neufeld, B Werner… - International journal …, 2014 - Taylor & Francis
The development of phased array transducers and their integration with magnetic
resonance (MR) guidance and thermal monitoring has established transcranial MR-guided …

Transcranial ultrasound neuromodulation of the thalamic visual pathway in a large animal model and the dose-response relationship with MR-ARFI

M Mohammadjavadi, RT Ash, N Li, P Gaur… - Scientific Reports, 2022 - nature.com
Neuromodulation of deep brain structures via transcranial ultrasound stimulation (TUS) is a
promising, but still elusive approach to non-invasive treatment of brain disorders. The …