Amino acid networks (AANs) are undirected networks consisting of amino acid residues and
their interactions in three-dimensional protein structures. The analysis of AANs provides …

Network theory has become an excellent method of choice through which biological data
are smoothly integrated to gain insights into complex biological problems. Understanding …

Alternative techniques and tools for analyzing biomolecular networks With the recent rapid
advances in molecular biology, high-throughput experimental methods have resulted in …

Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs
targeting the same protein. Here, we overview the current knowledge on allosteric signal …

The emerging structural information about allosteric kinase complexes and the growing
number of allosteric inhibitors call for a systematic strategy to delineate and classify …

Small world network concepts provide many new opportunities to investigate the complex
three dimensional structures of protein molecules. This mini-review explores the published …

The phenomenon of intra-protein communication is fundamental to such processes as
allostery and signaling, yet comparatively little is understood about its physical origins …

The fundamental role of the Hsp90 chaperone in supporting functional activity of diverse
protein clients is anchored by specific cochaperones. A family of immune sensing client …

The traditional view of enzymes as being composed of dense networks of amino acids that
interact locally is widely accepted, yet it is incomplete.[1] Recent research has shown that …

Protein–DNA interactions are pivotal to various cellular processes. Precise identification of
the hotspot residues for protein–DNA interactions holds great significance for revealing the …