Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Physical activity and exercise training have numerous health benefits, including the
prevention and management of chronic diseases, improvement of cardiovascular health …

Exercise promotes adipose remodeling and improves obesity-induced metabolic disorders
through mechanisms that remain obscure. Here, we identify the FGF21 signaling in adipose …

Regular exercise reduces the risks for cardiovascular diseases. Although the gut microbiota
has been associated with fitness level and cardiometabolic risk factors, the effects of …

Aging is a complex process that features a functional decline in many organelles. Various
factors influence the aging process, such as chromosomal abnormalities, epigenetic …

Different forms of physical activity—endurance, resistance or dynamic power—stimulate
cytokine release from various tissues to the bloodstream. Receptors for exercise-induced …

The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for
obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate …

Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the
American College of Sports Medicine Page 1 Physical Activity and Nonalcoholic Fatty Liver …

Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family, which functions
as a powerful endocrine and paracrine regulator of glucose and lipid metabolism. In addition …

Aims/hypothesis Pharmacological doses of FGF21 improve glucose tolerance, lipid
metabolism and energy expenditure in rodents. Induced expression and secretion of FGF21 …