The therapeutic landscape of rheumatoid arthritis: current state and future directions

S Shams, JM Martinez, JRD Dawson, J Flores… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis

T Frangos, W Maret - Nutrients, 2020 - mdpi.com
Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory articular conditions with
different aetiology, but both result in joint damage. The nutritionally essential metal zinc …

Proinflammatory cytokines (IL-1,-6,-8,-15,-17,-18,-23, TNF-α) single nucleotide polymorphisms in rheumatoid arthritis—a literature review

OM Koper-Lenkiewicz, K Sutkowska… - International Journal of …, 2022 - mdpi.com
Conducted studies highlight that a mixture of genetic and environmental factors is
responsible for rheumatoid arthritis (RA) development. This study aimed to analyze the …

Cell-free DNA in rheumatoid arthritis

T Hashimoto, K Yoshida, A Hashiramoto… - International journal of …, 2021 - mdpi.com
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream
following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is …

Dynamic Release from Acetalated Dextran Nanoparticles for Precision Therapy of Inflammation

G Erensoy, L Råberg, U von Mentzer… - ACS Applied Bio …, 2024 - ACS Publications
Polymer-based nanoparticles (NPs) that react to altered physiological characteristics have
the potential to enhance the delivery of therapeutics to a specific area. These materials can …

Application of germline antibody features to vaccine development, antibody discovery, antibody optimization and disease diagnosis

Y Zhang, Q Li, L Luo, C Duan, J Shen, Z Wang - Biotechnology Advances, 2023 - Elsevier
Although the efficacy and commercial success of vaccines and therapeutic antibodies have
been tremendous, designing and discovering new drug candidates remains a labor-, time …

Prevention of rheumatoid arthritis using a familial predictive medicine approach

P Ruscitti, M Nunziato, F Caso, R Scarpa… - Autoimmunity …, 2024 - Elsevier
Most of the chronic-degenerative diseases deserve a very early recognition of symptoms
and signs for the earliest secondary prevention, which could be also very useful in many …

[PDF][PDF] Serum sCD25 is an indicator for rheumatoid arthritis-associated interstitial lung disease

S Cao, X Liu, Y Li, Y Yang, X Cai, S Cong… - Clin Exp …, 2024 - clinexprheumatol.org
Objective CD25 (IL-2Rα) is one of IL-2 receptor's polypeptide subunits, and its soluble form
is increased in patients with various inflammatory or autoimmune diseases. This study …

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

H Chen, X Fu, X Wu, J Zhao, F Qiu, Z Wang, Z Wang… - Bone Research, 2024 - nature.com
Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut
microbiota is environmentally acquired and associated with RA susceptibility. However …

Advances in experimental models of rheumatoid arthritis

S Wang, Y Zhou, J Huang, H Li, H Pang… - European journal of …, 2023 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by
persistent articular inflammation and joint damage. RA was first described over 200 years …