Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

The ongoing search for therapeutic interventions in Alzheimer disease (AD) has highlighted
the complexity of this condition and the need for additional biomarkers, beyond amyloid-β …

Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …

Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due
to their significant involvement in cognitive decline associated with neurological disorders …

Increasing evidence suggests that neuroinflammation contributes to the pathophysiology of
many neurodegenerative diseases, especially Alzheimer's disease (AD). Molecular imaging …

Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of
Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic …

Background The α7 nicotinic acetylcholine receptor increasingly has been implicated in
normal brain physiology, as well as in neuropsychiatric disorders. The highly cortical …

The inflammatory response is a major factor in stroke pathophysiology and contributes to
secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent …