Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

Airway epithelial cells are the first line of defense against invading microbes, and they
protect themselves through the production of carbohydrate and protein matrices …

Bacterial biofilms affect many areas of human activity including food processing,
transportation, public infrastructure, and most importantly healthcare. This study addresses …

Intracellular bacterial pathogens Francisella novicida and the Live Vaccine Strain (LVS) are
recognized in the macrophage cytosol by the AIM2 inflammasome, which leads to the …

Francisella tularensis is a highly-infectious bacterium that causes the rapid, and often lethal
disease, tularemia. Many studies have been performed to identify and characterize the …

Metabolic pathways are now considered as intrinsic virulence attributes of pathogenic
bacteria and thus represent potential targets for antibacterial strategies. Here we focused on …

Autophagy is a key innate immune response to intracellular parasites that promotes their
delivery to degradative lysosomes following detection in the cytosol or within damaged …

Bacterial lipopolysaccharides (LPSs) are ubiquitous molecules that are prominent
components of the outer membranes of most gram-negative bacteria. Genetic and structural …

Francisella tularensis is a Gram-negative bacterium capable of causing the zoonotic disease
tularaemia in a large number of mammalian species and in arthropods. F. tularensis is a …

In the present study, using the murine monocyte/macrophage cell line RAW264. 7 as a
model system, we analyzed the phagocytosis rate and the bactericidal capacity of …