Glial cells have a variety of functions in the brain, ranging from immune defense against
external and endogenous hazardous stimuli, regulation of synaptic formation, calcium …

Proper development and function of the mammalian central nervous system (CNS) depend
critically on the activity of parenchymal sentinels referred to as microglia. Although microglia …

Receptor for advanced glycation end products (RAGE) is a receptor of the immunoglobulin
super family that plays various important roles under physiological and pathological …

Alzheimer's disease (AD) is a major public health problem with substantial economic and
social impacts around the world. The hallmarks of AD pathogenesis include deposition of …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Amyloid β (Aβ) plays a pivotal role in the progression of Alzheimer's disease (AD) through its
neurotoxic and inflammatory effects. On one hand, Aβ binds to microglia and activates them …

One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …

Accumulation of β-Amyloid (βA) is a key pathogenetic factor in Alzheimer's disease;
however, the normal function of βA is unknown. Recent studies have shown that βA can …

Most chronic modern non-transmissible diseases seem to begin as the result of low-grade
inflammation extending over prolonged periods of time. The importance of diet as a source …

Emerging evidence suggests that the signalling of the Receptor for Advanced Glycation End
products (RAGE) is critical for skeletal muscle physiology controlling both the activity of …