Molecular signaling pathways play a significant role in the regulation of biological
mechanisms, and their abnormal expression can provide the conditions for cancer …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Triple-negative breast cancer is aggressive and metastatic breast cancer type and shows
immune evasion, drug resistance, relapse and poor survival. Anti-cancer therapy like …

Innate immunity plays an important role not only during infection but also homeostatic role
during stress conditions. Activation of the immune system including innate immune response …

As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

Multiple studies have identified metabolic changes within the tumor and its
microenvironment during carcinogenesis. Yet, the mechanisms by which tumors affect the …

Metastatic osteosarcoma often results in poor prognosis despite the application of surgical
en bloc excision along with chemotherapy. HO-3867 is a curcumin analog that induces cell …

Pulmonary arterial hypertension (PAH) is a devastating lung disease characterized by the
progressive obstruction of the distal pulmonary arteries (PA). Structural and functional …

Objectives Signal transducer and activator of transcription 3 (STAT3) is constitutively
activated and overexpressed in many cancers, including non–small‐cell lung cancer …

SH2 domains have been recognized as promising targets for various human diseases.
However, targeting SH2 domains with phosphopeptides or small-molecule inhibitors derived …