Delivery technologies for cancer immunotherapy

RS Riley, CH June, R Langer, MJ Mitchell - Nature reviews Drug …, 2019 - nature.com
Immunotherapy has become a powerful clinical strategy for treating cancer. The number of
immunotherapy drug approvals has been increasing, with numerous treatments in clinical …

Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo

T DiTommaso, JM Cole, L Cassereau… - Proceedings of the …, 2018 - National Acad Sciences
The translational potential of cell-based therapies is often limited by complications related to
effectively engineering and manufacturing functional cells. While the use of electroporation …

T cells and reactive oxygen species

AV Belikov, B Schraven, L Simeoni - Journal of biomedical science, 2015 - Springer
Reactive oxygen species (ROS) have been long considered simply as harmful by-products
of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also …

Delivery strategies of cancer immunotherapy: recent advances and future perspectives

Z Zhao, L Zheng, W Chen, W Weng, J Song… - Journal of hematology & …, 2019 - Springer
Immunotherapy has become an emerging strategy for the treatment of cancer.
Immunotherapeutic drugs have been increasing for clinical treatment. Despite significant …

[HTML][HTML] Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

Y Zhu, X Yu, SD Thamphiwatana, Y Zheng… - … Pharmaceutica Sinica B, 2020 - Elsevier
Cancer immunotherapy has veered the paradigm of cancer treatment. Despite recent
advances in immunotherapy for improved antitumor efficacy, the complicated tumor …

A comprehensive review on intracellular delivery

D Morshedi Rad, M Alsadat Rad… - Advanced …, 2021 - Wiley Online Library
Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Materials for improving immune cell transfection

ARK Kumar, Y Shou, B Chan, A Tay - Advanced Materials, 2021 - Wiley Online Library
Chimeric antigen receptor T cell (CAR‐T) therapy holds great promise for preventing and
treating deadly diseases such as cancer. However, it remains challenging to transfect and …

Recent Advances in Microfluidic Platforms for Programming Cell‐Based Living Materials

P Zhang, N Shao, L Qin - Advanced Materials, 2021 - Wiley Online Library
Cell‐based living materials, including single cells, cell‐laden fibers, cell sheets, organoids,
and organs, have attracted intensive interests owing to their widespread applications in …

Approaches and materials for endocytosis-independent intracellular delivery of proteins

N Chen, Y He, M Zang, Y Zhang, H Lu, Q Zhao… - Biomaterials, 2022 - Elsevier
The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …