Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Emerging evidence suggests that ascorbate, the dominant form of vitamin C under
physiological pH conditions, influences activity of the genome via regulating epigenomic …

Cancer cells require a steady source of metabolic energy in order to continue their
uncontrolled growth and proliferation. Accelerated glycolysis is one of the biochemical …

Extracellular stimuli signal for activation of the transcription factor NFκB, leading to gene
expression regulating processes involved in immune responses, inflammation, and cell …

The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect
for the understanding of the roles played by this vitamin in pathophysiology. Considerable …

Over the past few years it has become clear that vitamin C, as a provider of reduced iron, is
an essential factor for the function of epigenetic regulators that initiate the demethylation of …

The GLUT2 glucose transporter and the K‐ATP‐sensitive potassium channels have been
implicated as an integral part of the glucose‐sensing mechanism in the pancreatic islet β …

The effect of ascorbic acid on cancer has been a subject of great controversy. This is a follow-
up review of the 1979 article by Cameron, Pauling, and Leibovitz published in Cancer …

Human tumors may contain high concentrations of ascorbic acid, but little is known about
how they acquire the vitamin. Certain specialized cells can transport ascorbic acid directly …

Human cells transport dehydroascorbic acid through facilitative glucose transporters, in
apparent contradiction with evidence indicating that vitamin C is present in human blood …