In this contribution, we provide a comprehensive overview of acyclic twisted amides,
covering the literature since 1993 (the year of the first recognized report on acyclic twisted …

Over the years biomedical research has been constantly oriented towards the development
of new therapeutics based on bioactive peptides and their analogues. In particular, the …

Copper-catalyzed azide alkyne cycloadditions of the linear substrates 1 were used to form
the cyclic derivatives 2. Computational, NMR, and CD analyses of these compounds …

A direct approach to the synthesis of indolizidine and quinolizidine scaffolds of iminosugars
is described. The presented strategy is based on a one-pot sugar lactam reduction with …

Abstract The chapter describes the 1, 3‐dipolar cycloadditions of cyclic nitrones with alkenes
and surveys the literature from 1985 to 2014. In addition to comprehensive coverage of the …

Recently, a novel type of antimicrobial and proteolytically stable peptidomimetic oligomers
having an α-peptide-β-peptoid chimeric backbone was reported. The present paper …

Starting from advanced pyrrolidin-2-one lead compounds, this novel series of small-
molecule orexin receptor antagonists was further optimized by fine-tuning of the C-3 …

1, 3-Dipolar cycloaddition reaction of nitrone 7 and chemo-enzymatically obtained
alkenediols 12 and 13 has been used in the synthesis of pentahydroxylated pyrrolizidines (8 …

For the last 50 years many scientists have drawn special attention to nitrones due to their
successful application as building blocks in the synthesis of various natural and biologically …

A highly efficient total synthesis of (±)-yohimbenone and a formal synthesis of (±)-emetine is
described. The key element of the synthesis consists of a conjugate addition− dipolar …