The respiratory tract is an important site of immune regulation; required to allow protective
immunity against pathogens, while minimizing tissue damage and avoiding aberrant …

Members of the interleukin 12 (IL-12) family have been known to be inflammatory factors
since their discovery. The IL-12 family consists of IL-12, IL-23, IL-27, IL-35, and a new …

Autoimmune diseases contain a large number of pathologies characterized by various
factors that contribute to a breakdown in self-tolerance. Cytokine-mediated immunity plays …

Previous studies have demonstrated that targeting inflammation is a promising strategy for
treating lipopolysaccharide (LPS)-induced sepsis and related heart injury. Interleukin-35 (IL …

Asthma is a common respiratory disease that has no definitive treatment at now. Immune
response shifting from T helper (Th) 1 to the Th2 is a main problem in asthma, and …

Asthma is a chronic airway inflammation that is characterized by intense eosinophil
infiltrates, mucus hypersecretion, airway remodeling, and airway hyperresponsiveness …

Purpose Allergen exposure induces aberrant T helper (Th) 2 immune responses in patients
with allergic asthma, but not in sensitized asymptomatic and nonallergic subjects. Interleukin …

Background: IL-35 was recently identified as an anti-inflammatory cytokine. We previously
reported that recombinant fusion protein of murine IL-35 and human IgG1 Fc fragment (rIL …

Cigarette smoke (CS) facilitates adverse effects on the airway inflammation and treatment of
asthma. Here, we investigated the mechanisms by which CS exacerbates asthma. The roles …

Asthma is defined as a heterogeneous disease, usually characterized by chronic airway
inflammation. Long noncoding RNAs (lncRNAs) play important roles in various biological …