[HTML][HTML] Animal models of PTSD: a challenge to be met

G Richter-Levin, O Stork, MV Schmidt - Molecular psychiatry, 2019 - nature.com
Recent years have seen increased interest in psychopathologies related to trauma
exposure. Specifically, there has been a growing awareness to posttraumatic stress disorder …

[HTML][HTML] Cell-type-specific epigenetic effects of early life stress on the brain

MF Rahman, PO McGowan - Translational Psychiatry, 2022 - nature.com
Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased
vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA …

International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023

TP Burris, IMS de Vera, I Cote, CA Flaveny… - Pharmacological …, 2023 - ASPET
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Unraveling the epigenetic landscape of depression: focus on early life stress

A Torres-Berrío, O Issler, EM Parise… - Dialogues in clinical …, 2019 - Taylor & Francis
Depression is a devastating psychiatric disorder caused by a combination of genetic
predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular …

Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation

PJ Lucassen, CA Oomen… - Cold Spring …, 2015 - cshperspectives.cshlp.org
Exposure to stress is one of the best-known negative regulators of adult neurogenesis (AN).
We discuss changes in neurogenesis in relation to exposure to stress, glucocorticoid …

Neonatal maternal separation impairs prefrontal cortical myelination and cognitive functions in rats through activation of Wnt signaling

Y Yang, Z Cheng, H Tang, H Jiao, X Sun, Q Cui… - Cerebral …, 2017 - academic.oup.com
Adverse early-life experience such as depriving the relationship between parents and
children induces permanent phenotypic changes, and impairs the cognitive functions …

Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats

DD Shi, YD Zhang, YY Ren, SY Peng, TF Yuan… - Molecular …, 2021 - nature.com
Early-life stress is normally thought of as a major risk for psychiatric disorders, but many
researchers have revealed that adversity early in life may enhance stress resilience later in …

[HTML][HTML] The moderating effects of sex on consequences of childhood maltreatment: from clinical studies to animal models

JD White, A Kaffman - Frontiers in neuroscience, 2019 - frontiersin.org
Stress has pronounced effects on the brain, and thus behavioral outputs. This is particularly
true when the stress occurs during vulnerable points in development. A review of the clinical …

[HTML][HTML] Premenstrual dysphoric disorder and childhood maltreatment, adulthood stressful life events and depression among Lebanese university students: a …

Y Younes, S Hallit, S Obeid - BMC psychiatry, 2021 - Springer
Abstract Background Premenstrual Syndrome (PMS) is a cyclic sequence of physical and
behavioral symptoms that arise in the second half of the menstrual cycle. The extreme type …

DNA methylation signature as a biomarker of major neuropsychiatric disorders

Z Shirvani-Farsani, Z Maloum… - Journal of Psychiatric …, 2021 - Elsevier
DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …