The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

The use of human pluripotent stem cells for in vitro disease modelling and clinical
applications requires protocols that convert these cells into relevant adult cell types. Here …

Blood vessels are fundamental to animal life and have critical roles in many diseases, such
as stroke, myocardial infarction and diabetes. The vasculature is formed by endothelial cells …

Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells
(iPSCs) to a variety of lineages requires step-wise approaches replicating the key …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

The circulatory system is the first organ system to develop in the vertebrate embryo and is
critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of …

Blood cells are constantly produced in the bone marrow (BM) of adult mammals. This
constant turnover ultimately depends on a rare population of progenitors that displays self …

Transforming growth factor (TGF)-βs and their family members, including bone
morphogenetic proteins (BMPs), Nodal and activins, have been implicated in the …

The onset of hematopoiesis in the mouse embryo and in the embryonic stem (ES) cell
differentiation model is defined by the emergence of the hemangioblast, a progenitor with …