The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

BACKGROUND: The initiation and progression of various types of tumors, including glioma,
are driven by a population of cells with stem cell properties. Glioma stem cells (GSCs) are …

Background Aberrant activation of the Hedgehog pathway drives tumorigenesis of many
cancers, including glioblastoma. However, the sensitization mechanism of the G protein …

Long noncoding RNAs (lncRNAs) are implicated as novel drivers in hepatocellular
carcinoma (HCC), but the underlying mechanisms of this relationship with …

Microenvironmental regulation of cancer stem cells (CSCs) strongly influences the onset
and spread of cancer. The way in which glioma cells interact with their microenvironment …

Plakoglobin (also known as?-catenin) is a member of the Armadillo family of proteins and a
paralog of β-catenin. Plakoglobin is a component of both the adherens junctions and …

Epigenetics is the process by which gene expression is regulated by events other than
alterations of the genome. This includes DNA methylation, histone modifications, chromatin …

Background: Several evidences suggest a marked angiogenic dependency in triple-
negative breast cancer (TNBC) tumorigenesis and a potential sensitivity to anti-angiogenic …

Disruptions to developmental cell signaling pathways and transcriptional cascades have
been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant …

Sonic hedgehog (Shh) signaling influences neurogenesis and neural patterning during the
development of central nervous system. Dysregulation of Shh signaling in brain leads to …