Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons

M García, A Carrasco García, W Weigel, W Christ… - PLoS …, 2024 - journals.plos.org
Hantaviruses cause the acute zoonotic diseases hemorrhagic fever with renal syndrome
(HFRS) and hantavirus pulmonary syndrome (HPS). Infected patients show strong systemic …

LncRNA NEAT1 potentiates SREBP2 activity to promote inflammatory macrophage activation and limit Hantaan virus propagation

Y Yang, M Li, Y Ma, W Ye, Y Si, X Zheng, H Liu… - Frontiers in …, 2022 - frontiersin.org
As the global prototypical zoonotic hantavirus, Hantaan virus (HTNV) is prevalent in Asia
and is the leading causative agent of severe hemorrhagic fever with renal syndrome …

Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection

R Ma, X Zhang, J Shu, Z Liu, W Sun, S Hou… - Frontiers in …, 2021 - frontiersin.org
Hantaan virus (HTNV) infects humans and causes hemorrhagic fever with renal syndrome
(HFRS). The development of well-characterized animal models of HFRS could accelerate …

Hantavirus infection-induced B cell activation elevates free light chains levels in circulation

J Hepojoki, LE Cabrera, S Hepojoki, C Bellomo… - PLoS …, 2021 - journals.plos.org
In humans, orthohantaviruses can cause hemorrhagic fever with renal syndrome (HFRS) or
hantavirus pulmonary syndrome (HPS). An earlier study reported that acute Andes virus …

A three-dimensional vessel-on-chip model to study Puumala orthohantavirus pathogenesis

D Noack, A van Haperen, MCGN van den Hout… - Lab on a Chip, 2024 - pubs.rsc.org
Puumala orthohantavirus (PUUV) infection in humans can result in hemorrhagic fever with
renal syndrome. Endothelial cells (ECs) are primarily infected with increased vascular …

Neutralizing antibody titers in hospitalized patients with acute Puumala orthohantavirus infection do not associate with disease severity

R Iheozor-Ejiofor, K Vapalahti, T Sironen, L Levanov… - Viruses, 2022 - mdpi.com
Nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome
(HFRS), is an acute febrile illness caused by Puumala orthohantavirus (PUUV). NE …

A Pan-RNase Inhibitor Enabling CRISPR-mRNA Platforms for Engineering of Primary Human Monocytes

K Laoharawee, MJ Johnson, WS Lahr, CJ Sipe… - International journal of …, 2022 - mdpi.com
Monocytes and their downstream effectors are critical components of the innate immune
system. Monocytes are equipped with chemokine receptors, allowing them to migrate to …

Increased blood CD226- inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome

K Tang, Y Hou, L Cheng, Y Zhang, J Li, Q Qin… - Annals of …, 2023 - Taylor & Francis
Background Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal
syndrome (HFRS). Inflammatory monocytes (iMOs) are involved in early antiviral responses …

[HTML][HTML] Hantavirus Research in Finland

J Mustonen, T Strandin, J Tietäväinen, I Pörsti… - Viruses, 2024 - mdpi.com
The articles in this Special Issue,“Hantavirus Research in Finland”, were published between
2021 and 2022. In this closing editorial, we comment on some of these papers, with a …

Acute Pancreatitis and Leukemoid Reaction as the Presenting Manifestation of Hemorrhagic Fever with Renal Syndrome: A Case Report

L Zhong, H Shi, H Li, L Xiao, Q Peng, Z Liu… - Infection and Drug …, 2024 - Taylor & Francis
Background Hemorrhagic fever with renal syndrome (HFRS), caused by Orthohantavirus
hantanense (HTNV) infection, is characterized by a range of symptom including fever …