Gene therapy holds great promise for treating a multitude of inherited and acquired diseases
by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit …

1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

Nonviral gene therapy holds great promise but has not delivered treatments for clinical
application to date. Lack of safe and efficient gene delivery vectors is the major hurdle …

The construction of complex polymer architectures with well-defined topology, composition
and functionality has been extensively explored as the molecular basis for the development …

Barriers to therapeutic transport in biological systems can prevent accumulation of drugs at
the intended site, thus limiting the therapeutic effect against various diseases. Advances in …

Current therapies for most neurodegenerative disorders are only symptomatic in nature and
do not change the course of the disease. Gene therapy plays an important role in disease …

Recent advances in molecular biology have led to the CRISPR revolution, but the lack of an
efficient and safe delivery system into cells and tissues continues to hinder clinical …

Non-viral gene therapy for hereditary skin diseases is an attractive prospect. However,
research efforts dedicated to this area are rare. Taking advantage of the branched structural …

Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles,
which have highly interesting properties for therapeutic delivery and imaging. Nanogels may …

Poly (β-amino ester) s (PAEs) have emerged as a promising class of gene delivery vectors
with performances that can even be compared to viruses. However, all of the transfection …