T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum,
controls food transport, digestion, nutrient uptake, and hormone production. By single-cell …

The mammalian intestine is covered by a single layer of epithelial cells that is renewed
every 4–5 days. This high cell turnover makes it a very attractive and comprehensive adult …

The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical
behaviour and response to therapy translates into an urgent need for robust molecular …

Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of
diagnosis. The mechanisms that confer this rapid metastatic capacity to lung tumors are …

The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and in
many other adult organs. The transcription factor Ascl2 (a Wnt target gene) is a master …

Functional interpretation of candidate gene lists is an essential task in modern biomedical
research. Here, we present the 2011 update of g: Profiler (http://biit. cs. ut. ee/gprofiler/), a …

The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …

The canonical Wnt pathway has gathered much attention in recent years owing to its
fundamental contribution to metazoan development, tissue homeostasis and human …