Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and-2
WL Smith, MG Malkowski - Journal of Biological Chemistry, 2019 - ASBMB
Prostaglandin endoperoxide H synthases-1 and-2, commonly called cyclooxygenases-1
and-2 (COX-1 and-2), catalyze the committed step in prostaglandin biosynthesis—the …
and-2 (COX-1 and-2), catalyze the committed step in prostaglandin biosynthesis—the …
Renal medullary interstitial COX-2 (cyclooxygenase-2) is essential in preventing salt-sensitive hypertension and maintaining renal inner medulla/papilla structural …
MZ Zhang, S Wang, Y Wang, Y Zhang, C Ming Hao… - …, 2018 - Am Heart Assoc
COX (cyclooxygenase)-derived prostaglandins regulate renal hemodynamics and salt and
water homeostasis. Inhibition of COX activity causes blood pressure elevation. In addition …
water homeostasis. Inhibition of COX activity causes blood pressure elevation. In addition …
Molecular characterization of PANoptosis-related genes in chronic kidney disease
W Zhang, H Ge, Y Wei, J Gao, F Tian, E Zhou - Plos one, 2024 - journals.plos.org
Chronic kidney disease (CKD) is characterized by fibrosis and inflammation in renal tissues.
Several types of cell death have been implicated in CKD onset and progression. Unlike …
Several types of cell death have been implicated in CKD onset and progression. Unlike …
Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy
X Li, LL Ballantyne, MC Crawford, GA FitzGerald… - Scientific Reports, 2018 - nature.com
The participation of cyclooxygenase (COX) in embryo implantation and parturition has been
studied extensively. However, the distinct role of the two COX isoforms in these processes …
studied extensively. However, the distinct role of the two COX isoforms in these processes …
Integrated analysis of comprehensive metabolomics and network pharmacology to reveal the mechanisms of abelmoschus manihot (L.) medik. in the treatment of …
JC Liao, CY Li, FM Teng, JY Yu, WZ Ju… - Frontiers in …, 2022 - frontiersin.org
Background: Abelmoschus manihot (L.) Medik (“Huangkui” in Chinese, HK) has been widely
used for the treatment of kidney diseases. Nephrotoxicity is the side effect of cisplatin …
used for the treatment of kidney diseases. Nephrotoxicity is the side effect of cisplatin …