Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

Age-associated B cells (ABCs) are formed under inflammatory conditions and are
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …

Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …

Nucleic acid–specific Toll-like receptors (TLRs) have been implicated in promoting disease
pathogenesis in systemic lupus erythematosus (SLE). Whether such TLRs mediate disease …

RNA-sensing TLRs are strategically positioned in the endolysosome to detect incoming
nonself RNA. RNase T2 plays a critical role in processing long, structured RNA into short …

Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has
identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

B cells expressing the transcription factor T-bet are found to have a protective role in viral
infections, but are also considered major players in the onset of different types of …

Abstract Poor response to Bacillus Calmette-Guérin (BCG) immunotherapy remains a major
barrier in the management of patients with non–muscle invasive bladder cancer (NMIBC) …