The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Conspectus Cationic polymers have been investigated as nonviral vectors for gene delivery
due to their favorable safety profile when compared to viral vectors. However, nonviral …

During the last two decades, cationic polymers have become one of the most promising
synthetic vectors for gene transfection. However, the weak interactions formed between DNA …

Polyplex-mediated gene transfection is now in its' fourth decade of serious research, but the
promise of polyplex-mediated gene therapy has yet to fully materialize. Only approximately …

Cationic polymers dynamically complex DNA into complexes (polyplexes). So, upon dilution,
polyplexes easily dissociate and lose transfection ability, limiting their in vivo systemic gene …

Biomaterials such as spider silk and mussel byssi are fabricated by the dynamic
manipulation of intra‐and intermolecular biopolymer interactions. Organisms modulate …

Complex coacervates of hyaluronic acid and lysozyme, a model protein, were formed by
ionic interaction using bulk mixing and were characterized in terms of binding stoichiometry …

Developing improved cationic polymer–DNA polyplexes for gene delivery requires improved
understanding of DNA transport from endosomes into the nucleus. Using a FRET-capable …

Complexation of oppositely charged macromolecules is essential in several biological
phenomena. Recent reports have demonstrated the importance of DNA local flexibility in …

Cationic gene delivery agents (vectors) are important for delivering nucleotides, but are also
responsible for cytotoxicity. Cationic polymers (L-PEI, jetPEI, and G5 PAMAM) at 1× to 100× …